atlas

BraiAn is an open-source suite of tools designed to simplify signal quantification, analysis and visualization of large datasets typically obtained in whole-brain imaging experiments, following registration to an atlas. 

The package consists of two separate modules.

1. BrainAnDetect: A QuPath extension for multi-channel cell segmentation across large and variable datasets. It leverages QuPath's built in algorithms for cell detection, and features additional options for refining signal quantification, including machine-learning-based object classification, region-specific cell segmentation, multiple marker co-expression analysis, and an interface for selective exclusion of damaged tissue portions.
2. BraiAnalyse: A modular Python library for the easy navigation, visualization, and analysis of whole-brain quantification outputs.

Aligning Big Brains & Atlases (ABBA) is a set of software components which allows users to register images of thin serial biological tissue sections, cut in any orientation (coronal, sagittal or horizontal) to atlases, usually brain atlases. ABBA is available as a Fiji plugin for performing registration; a QuPath extension is also available and recommended. Typically, a set of serial sections is defined as a QuPath project, that is registered within Fiji. The registration results can then imported back into QuPath for downstream processing (cell detection and classification, cell counting per region, etc.).

Available atlases include the 3D mouse Allen Brain atlas and the Waxholm Space Atlas of the Sprague Dawley Rat Brain. Depending on your installation method, you may also access all BrainGlobe atlases.

ClearMap is a toolbox for the analysis and registration of volumetric data from cleared tissues.

It was initially developed to map brain activity at cellular resolution in whole mouse brains using immediate early gene expression. It has since then been extended as a tool for the qunatification of whole mouse brain vascualtur networks at capilary resolution.

It is composed of sevral specialized modules or scripts: tubemap, cellmap, WobblyStitcher.

ClearMap has been designed to analyze O(TB) 3d datasets obtained via light sheet microscopy from iDISCO+ cleared tissue samples immunolabeled for proteins. The ClearMap tools may also be useful for data obtained with other types of microscopes, types of markers, clearing techniques, as well as other species, organs, or samples.

The Virtual Brain Explorer (ViBE-Z) is a software that automatically maps gene expression data with cellular resolution to a 3D standard larval zebrafish (Danio rerio) brain. It automatically detects 14 predefined anatomical landmarks for aligning data. It also offers a database and atlas. The ViBE-Z database, atlas and software are provided via a web interface. A data preparation step is needed in order to provide the right input data and format.